- Interstate 55
- Close proximity to Interstates 24 and 57
- U.S. Highway 61
- Close Proximity to U.S. Highway 60
- Missouri Highways 74, 72, 25, 34 and 177
- Illinois Highways 3 and 146
Cape Girardeau County Transit Authority offers safe, reliable and cost effective transit service to all citizens of Cape Girardeau County. Services include demand response vehicles, deviated fixed route services, courier service and private service contracts.
Cape Girardeau Regional Airport offers daily flights to St. Louis in partnership with Cape Air and also provides Air Charter services.
Huskey Trailways and Southwestern Illinois Bus Company provide chartered trips to different destinations.